University of Waterloo
Systems Design Engineering
SYDE 444 Biomedical Engineering: Human Function and Its Measurement

Final Examination

April 21, 1999.

D. Stashuk

Answer 25 of the 30 questions in the examination booklets provided. No aids allowed
Measurement and Instrumentation Systems 2 Questions (4 marks each Total 8):
1. Briefly, discuss some of the affects of two different technologies, which have been developed in the 20th century, on health care delivery.
2. Briefly, discuss some of the major factors that need to be considered when obtaining measurements from a living system.
Physiology of Excitable Cells and the Origin of Biopotentials 4 Questions (4 marks each Total 16):
3. Briefly, describe the structure of the membrane of an excitable cell. Include the elements and aspects of the membrane that allow the cell to be excitable.
4. Briefly, explain the creation of a Nernst potential.
5. What aspects of an excitable cell determine its membrane potential?
6. Briefly, explain why the amplitude of a current pulse, required to elicit an action potential in an excitable cell, decreases as it duration increases. Also, explain why there is a minimum amplitude for the current pulse, even if it is infinitely long.
Biopotential Electrodes 2 Questions (4 marks each Total 8):
7. Why are nonpolarizable electrodes so widely used?
8. Briefly, describe the fundamental principles of operation of a carbon dioxide electrode.
Skeletal Muscle System 5 Questions (4 marks each Total 20):
9. Briefly, compare and contrast skeletal and cardiac muscle fibres.
10. Briefly, describe muscle spindles and their role in peripheral muscle control.
11. Briefly, describe the composition of a motor unit action potential.
12. Briefly, discuss how characteristics of needle detected motor unit action potentials can be used to determine the state of health of a specific muscle.
13. Briefly, describe how and why EMG signals can be detected and processed to measure muscle force.
Central Nervous System 5 Questions (4 marks each Total 20):
14. Briefly, describe the basil ganglia, its location and primary function.
15. Briefly, what can be the affect of injury to the spinal cord and why? What determines the extent of the affect of a spinal cord injury?
16. Briefly, compare and contrast EEG and EMG signals.
17. Briefly, discuss how and why EEG signals can be used?
18. How are auditory evoked potentials obtained? How can they be used?
Cardiovascular System 6 Questions (4 marks each Total 24):
19. Briefly, explain why the left ventricle of the heart is much bigger and stronger than the right ventricle. Briefly, explain the purpose and operation of the valves of the heart.
20. Briefly, explain why SA node cardiac fibres have the shortest refractory period. What are some of the consequences of an improperly functioning AV node?
21. Briefly, discuss one method for measuring cardiac output. Include some of the advantages and disadvantages of the technique discussed.
22. Briefly, describe the major components of an ECG waveform and what cardiac activity they are related to. How can these components can be used clinically?
23. What is considered competitive stimulation by a cardiac pacemaker? Why is competitive stimulation potentially unsafe and how can it be avoided?
24. Why are cardiac pacemaker electrodes as small as possible, while cardiac defibrillator electrodes are as large as possible?
Medical Imaging 6 Questions (4 marks each Total 24):
25. What are two different methods of controlling the intensity of X-rays created by an X-ray tube? Which of these two methods is used to create diagnostic X-ray and why?
26. Briefly, explain why contrasting substances such as barium sulphate are used to obtain X-ray images of the gastro-intestinal tract.
27. Briefly, describe how X-ray CT scans are obtained and what determines their resolution.
28. Briefly, explain the spin warp (phase encoding) method of obtaining MR images.
29. Briefly, explain what factors determine the thickness of the tissue layer contributing to an MR image.
30. Briefly, explain the sequence of excitation pulses required to use both the spin-lattice and spin-spin relaxation properties of a tissue to obtain contrast in an MR image.

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